Guthrie High School is proud of all their state championships throughout their school history. Here is the list of team championships.
| 1923 | State-National Champions | Girls Basketball |
| 1924 | National Champion | Girls Basketball |
| 1939 | State Champion | Girls Golf |
| 1940 | State Champion | Girls Golf |
| 1954 | State Champion | Boys Basketball |
| 1956 | State Champion | Boys Basketball |
| 1968 | State Champion | Boys Basketball |
| 1969 | State Champion | Boys Basketball |
| 1979 | State Champion | Girls Golf |
| 1981 | State Champion | Wrestling |
| 1983 | State Champion | Boys Cross Country |
| 1984 | State Champion | Boys Cross Country |
| 1989 | State Champion | Baseball |
| 1990 | State Champion | Girls Basketball |
| 1991 | State Champion | Boys Cross Country |
| 1992 | State Champion | Boys Golf |
| 1994 | State Champion | Boys Cross Country |
| 1995 | Academic State Champion | Boys Tennis |
| 1996 | Academic State Champion | Boys Tennis |
| 1997 | Academic State Champion | Baseball |
| 1997 | Academic State Champion | Boys Cross Country |
| 1998 | State Champion | Boys Golf |
| 2002 | State Champion | Football |
| 2003 | State Champion | Girls Cross Country |
| 2004 | Academic State Champion | Baseball |
| 2005 | Academic State Champion | Girls Track |
| 2007 | State Champion | Football |
| 2008 | State Champion | Boys Basketball |
| 2009 | State Champion | Boys Basketball |
| 2009 | State Champion | Boys Track |
| 2009 | State Champion | Boys Cross Country |
| 2010 | State Champion | Boys Track |
| 2010 | Academic State Champion | Boys Track |
| 2010 | State Champion | Boys Cross Country |
| 2011 | Academic State Champion | Girls Golf |
| 2011 | State Champion | Football |
| 2012 | Academic State Champion | Wrestling |
| 2013 | Academic State Champion | Boys Cross Country |
| 2013 | State Champion | Football |
| 2018 | State Champion | Boys Golf |
| 2019 | Academic State Champion | Wrestling |
| 2019 | State Champion | Boys Golf |
| SPORT | STATE CHAMPIONSHIPS | ACADEMIC STATE CHAMPIONSHIPS |
| BASEBALL | 1 | 2 |
| BOYS BASKETBALL | 6 | – |
| GIRLS BASKETBALL | 2 | – |
| BOYS CROSS COUNTRY | 6 | 3 |
| GIRLS CROSS COUNTRY | 1 | – |
| FOOTBALL | 4 | – |
| BOYS GOLF | 4 | – |
| GIRLS GOLF | 3 | 1 |
| SOFTBALL | – | – |
| BOYS TENNIS | – | 2 |
| GIRLS TRACK | – | 1 |
| BOYS TRACK | 2 | 1 |
| WRESTLING | 1 | 2 |